Multiple sclerosis MS agents

SLF1081851 is a Spns2 inhibitor, inhibits S1P release ( IC 50 =1.93 μM). SLF1081851 plays a key role in development and immune systemIn VitroSphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule, and Spns2 exerts the functions to

SLF1081851 is a Spns2 inhibitor, inhibits S1P release ( IC 50 =1.93 μM). SLF1081851 plays a key role in development and immune systemIn VitroSphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule, and Spns2 exerts the functions to

SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC 50 &lt:1 μM (patent WO2008128171A2).In VitroSM-433 exhibits strong inhibitory activity

SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC 50 &lt:1 μM (patent WO2008128171A2).In VitroSM-433 exhibits strong inhibitory activity

SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC 50 &lt:1 μM (patent WO2008128171A2).In VitroSM-433 exhibits strong inhibitory activity

SM-433, a Smac mimetic, function as inhibitor of inhibitor of apoptosis proteins (IAPs). SM-433 exhibits strong binding affinity XIAP BIR3 protein with an IC 50 &lt:1 μM (patent WO2008128171A2).In VitroSM-433 exhibits strong inhibitory activity

Antigen: portion of amino acids 100-150 of human SMAD3 Host: rabbit Cross Reactivity: (+) Bovine, canine, human, mouse, porcine, rat, and rhesus monkey SMAD3 predicted to react with chicken, Xenopus, and zebrafish SMAD3 Application(s): IHC and WB

A synthetic ligand specific for ROR&alpha and ROR&gamma (Kis = 172 and 111 nM, respectively) that functions as an inverse agonist inhibits TH17 cell differentiation and IL-17A secretion in cultured splenocytes and human PBMCs at 5 &muM 25 mg/kg

A synthetic ligand specific for ROR&alpha and ROR&gamma (Kis = 172 and 111 nM, respectively) that functions as an inverse agonist inhibits TH17 cell differentiation and IL-17A secretion in cultured splenocytes and human PBMCs at 5 &muM 25 mg/kg

A synthetic ligand specific for ROR&alpha and ROR&gamma (Kis = 172 and 111 nM, respectively) that functions as an inverse agonist inhibits TH17 cell differentiation and IL-17A secretion in cultured splenocytes and human PBMCs at 5 &muM 25 mg/kg

A synthetic ligand specific for ROR&alpha and ROR&gamma (Kis = 172 and 111 nM, respectively) that functions as an inverse agonist inhibits TH17 cell differentiation and IL-17A secretion in cultured splenocytes and human PBMCs at 5 &muM 25 mg/kg

InformationSRT3025 is an orally available small molecule activator of theSIRT1enzyme.TargetsSIRT1 (Cell-free assay)In vitroSRT3025 inhibits RANKL-induced osteoclast differentiation, fusion and resorptive capacity without affecting osteoclast