tyrosine & kinase Inhibitors Immunomodulating drug

Application Reactant for: Preparation of potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk)

(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC 50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of PDK1. PIF: The protein kinase C-related kinase 2

(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC 50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of PDK1. PIF: The protein kinase C-related kinase 2

(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC 50 value of 1.8 μM. (R)-PS210 targets to the PIF-binding pocket of PDK1. PIF: The protein kinase C-related kinase 2

A methylsulfanylimidazole that inhibits p38 MAP kinase (IC₅₀ = 0.90 &microM in vitro) potently blocks the release of TNF-&alpha and IL-1&beta from human peripheral blood mononuclear cells (IC₅₀s = 0.

A methylsulfanylimidazole that inhibits p38 MAP kinase (IC₅₀ = 0.90 &microM in vitro) potently blocks the release of TNF-&alpha and IL-1&beta from human peripheral blood mononuclear cells (IC₅₀s = 0.

A methylsulfanylimidazole that inhibits p38 MAP kinase (IC₅₀ = 0.90 &microM in vitro) potently blocks the release of TNF-&alpha and IL-1&beta from human peripheral blood mononuclear cells (IC₅₀s = 0.

A methylsulfanylimidazole that inhibits p38 MAP kinase (IC₅₀ = 0.90 &microM in vitro) potently blocks the release of TNF-&alpha and IL-1&beta from human peripheral blood mononuclear cells (IC₅₀s = 0.

Cell Line Origin Human bone osteosarcoma TK- Cell Line Description Cells are thymidine kinase deficient (TK-) and resistant to BUdR.143B and HOS (Sigma Catalogue number 87070202) originated from the same host: 143B is TK- and originated indirectly

General description Contains mainly N-acetylneuraminic acid. GM 3 and its derivatives play important roles in immunoregulation and in biosynthesis and metabolism of higher gangliosides.

2B-(SP) TFA is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3). 2B-(SP) TFA is readily phosphorylated by both the α and β isoforms of GSK-3.

General description The development of the anti-phosphotyrosine, clone 4G10 in 1989 was a monumental discovery for researchers. 4G10 was the first and is the best single monoclonal antibody for the detection tyrosine phosphorylation.