Aminophenazone cyclamate

A dual inhibitor of mPGES-1 and 5-LO (IC₅₀s = 0.4 and 0.2 &microM, respectively) reduces the synthesis of PGE2 and LTC4 during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response.

A dual inhibitor of mPGES-1 and 5-LO (IC₅₀s = 0.4 and 0.2 &microM, respectively) reduces the synthesis of PGE2 and LTC4 during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response.

A dual inhibitor of mPGES-1 and 5-LO (IC₅₀s = 0.4 and 0.2 &microM, respectively) reduces the synthesis of PGE2 and LTC4 during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response.

A dual inhibitor of mPGES-1 and 5-LO (IC₅₀s = 0.4 and 0.2 &microM, respectively) reduces the synthesis of PGE2 and LTC4 during zymosan-induced peritonitis in mice, resulting in a significantly diminished inflammatory response.

Biochem/physiol Actions RPL554 (Ensifentrine) is a long acting, potent and specific dual inhibitor of PDE 3/4 (phosphodiesterase 3 and 4). RPL554 displays a broad range of both bronchoprotective and anti-inflammatory activities.

Biochem/physiol Actions RPL554 (Ensifentrine) is a long acting, potent and specific dual inhibitor of PDE 3/4 (phosphodiesterase 3 and 4). RPL554 displays a broad range of both bronchoprotective and anti-inflammatory activities.

Tumor Necrosis Factor-Alpha (TNF-alpha) plays a major role in growth regulation, differentiation, inflammation, viral replication, tumorigenesis, and autoimmune diseases. Besides inducing hemorrhagic necrosis of tumors, TNF has been found to be