Nonsteroidal anti inflammatory indoles

A natural indole alkaloid with demonstrated beneficial effects in cancer, obesity, inflammation, and many other conditions an AhR antagonist (Ki = 28 nM), activator of TRPV1 (EC₅₀ = 45 nM), and inhibitor of signaling through NF-&kappaB.

3-(1-Piperazinylmethyl)indole, 95% 1g

A PARP1 inhibitor (IC₅₀ = 450 nM) that displays neuroprotective effects in cultured mouse cortical neurons also inhibits eosinophilic infiltration into airways of OVA-challenged mice and induces the regression of atherosclerotic plaques