MEK Inhibitor I is a cell-permeable, pyridine-containing, vinylogous cyanamide that has the ability to act as a selective and potent inhibitor of MEK with little activity towards MKK3 and MKK4. The compound displays significant affinity only towards ATP-bound MEK (i.e. noncompetitive with respect to ATP) and the demonstrated inhibition is noncompetitive with respect to ERK. Compared to U0126 in aqueous solutionsMEK Inhibitor I demonstrates superior potency, solubility, and stability. Additionally shown to protect against phorbol ester-mediated ear edema in mice.
Specification: Moligand™, ≥95%
Molecular Formula: C21H18N4OS
Molecular Weight: 374.46
PubChem CID: 69884981
Isomeric SMILES: C1=CC=C(C(=C1)N)S/C(=C(/C#N)\C2=CC=CC(=C2)C(C3=CC=NC=C3)O)/N
Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/M338480-SCI_23ea66fc75f90131fd999046bcd23460.pdf
- UPC:
- 51111726
- Condition:
- New
- Availability:
- 4-8 weeks
- Weight:
- 0.07 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- M338480-10mg
- CAS:
- 297744-42-4
- Product Size:
- 10mg
- Precautionary Statement Codes:
- P264
