General description
A cell-permeable, non-steroidal anti-inflammatory drug (NSAID) of the oxicam family which preferentially inhibits the inducible isoform of COX-2 (IC50 = 4.7 µM) relative to COX-1 (IC50 = 36.6 µM). Also inhibits the growth of colorectal cancer cells in vitro.
A cell-permeable, non-steroidal, anti-inflammatory drug (NSAID) of the oxicam family that preferentially inhibits the inducible isoform of cyclooxygenase-2 (COX-2; IC50 = 4.7 µM) relative to cyclooxygenase-1 (COX-1; IC50 = 36.6 µM). Also inhibits the growth of colorectal cancer cells in vitro.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
COX-2
Product does not compete with ATP.
Reversible: no
Target IC50: 4.7 µM, 36.6 µM against the inducible isoform of COX-2 relative to COX-1, respectively
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
Other Notes
Blanco, F.J., et al. 1999. J. Rheumatol. 26, 1366.
Davies, N.M., and Skjodt, N.M. 1999. Clin. Pharmacokinet. 36, 115.
Goldman, A.P., et al. 1998. Carcinogenesis 19, 2195.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51286901
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 444800-100MG