Menadione belongs to the Vitamin K class of compounds, which are necessary for the biosynthesis of prothrombin and other blood clotting factors. Menadione has demonstrated cytotoxic activity against a variety of cell culture lines and can induce apoptosis of cultured cells, such as osteoclasts and osteoblasts, via elevation of peroxide and superoxide radical levels. Applications Menadione is a prothrombogenic compound1 and is used as a model quinone in cell culture and in vivo investigations. Biochem/physiol Actions Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. Menadione is used as a phosphatase inhibitor and an inhibitor of mitochondrial DNA polymerase γ (pol γ). Menadione can be used as an oxidative injury (free radical generator) inducing agent. Synonyms: Vitamin K3, 2-Methyl-1,4-naphthoquinone CAS Number: 58-27-5 Molecular Formula: C11H8O2 Molecular Weight: 172.2 Beilstein Registry Number: 1908453 EC Number: 200-372-6 MDL Number: MFCD00001681
- UPC:
- 51111752
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 210225991
