Methotrexate hydrate (C09-0969-347)

DescriptionMethotrexate hydrate has been used:as a dihydrofolate (DHFR) inhibitor in sphere forming assay cultureas a component of dulbecco′ modified Eagle′s medium (DMEM) for selection of transfected cellsin viability and co-culture assaysPotent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistantPlasmodium vivaxmalaria parasites. Specification: tested according to USP MDL Number: MFCD00150847 Molecular Formula: C20H22N8O5·xH2O Molecular Weight: 454.44 (anhydrous basis) PubChem CID: 165528 Isomeric SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O.O Beilstein Registry Number: 70669 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/M476589-SCI_4f92f0f5d28fb1e61cda177085ac5cf2.pdf