Methyl isocyanoacetate undergoes direct aldol reaction with carbonyl compounds in the presence of solid-phase catechol-copper network catalyst to yield corresponding oxazolines . It also participates in four-component Ugi condensation reaction .
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Methyl isocyanoacetate undergoes direct aldol reaction with carbonyl compounds in the presence of solid-phase catechol-copper network catalyst to yield corresponding oxazolines. It also participates in four-component Ugi condensation reaction.
Methyl isocyanoacetate has been used in the copper-catalyzed, diastereoselective synthesis of oxazolines.
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