Methylglyoxal (C09-0939-512)

Methylglyoxal (MG) is a glucose metabolite, which is linked to peripheral neuropathy and pain in diabetic patients. It enhances intracellular calcium in sensory neurons and produces behavioral nociception. Methylglyoxal has antibacterial property. MG functions as a protein-glycating agent and precursor of advanced glycation end products. It impairs diabetic wound healing.Methylglyoxal solution has been used:to assess glyoxalase 1 (GLO1) enzymatic activity；as an advanced glycation end (AGE) forming agent for the preparation of albumin in vitro；to regulate anxiety like behavior in mice；to induce peritoneal fibrosis in rats；to study the chromatographic retention characteristics of organic chemicals and metal DNA adducts；for intraplantar injection in mice to investigate peripheral and central components of methylglyoxal (MG)-transient receptor potential ankyrin 1 (TRPA1)-adenylyl cyclase 1 isoform (AC1) pathway.Pyruvic aldehyde is used in the synthesis and cytotoxicity evaluation of N-terminal analogues of tubulysin-U an antimitotic compound. Also used in the synthesis of imidazoles as potent calcitonin gene-related CGRP antagonists. Specification: 40% solution MDL Number: MFCD00006960 Molecular Formula: C3H4O2 Molecular Weight: 72.06 PubChem CID: 880 Isomeric SMILES: CC(=O)C=O Beilstein Registry Number: 906750 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/M109035-SCI_fe0497c0aeca935c3b4c1645bcb6b6ec.pdf