General description
The coxsackievirus and adenovirus receptor (CAR) mediates cell attachment and infection by coxsackie B viruses and by a number of adenoviruses. CAR also mediates homotypic intercellular interactions. In polarized epithelial cells, CAR is closely associated with the tight junction, where it contributes to the barrier to paracellular flow of solutes and macromolecules. CAR′s biological roles are not well defined, but emerging evidence suggests that it may function during embryonic development and in regulating cell proliferation.
Specificity
Antibody recognizes CAR.
Immunogen
Native human coxsackie virus-adenovirus receptor protein
Application
Detect CAR using this Milli-Mark Anti-CAR-PE Antibody, clone RmcB validated for use in FC.
Research Category
Cell Structure
Research Sub Category
ECM Proteins
Quality
Evaluated by flow cytometry using HT-29 cells.
Target description
40 kDa Calculated. Uniprot indicates multiple isoforms ranging from 9 to 40 kDa
Physical form
Protein G Purified
Purified mouse monoclonal IgG1 conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Storage and Stability
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Analysis Note
Control
HT-29 cells
Other Notes
Unconjugated version Cat. No. 05-644 is known to react with Mouse and Rat.
Legal Information
MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
- UPC:
- 41116126
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- FCMAB418PE-I
