General description
A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III, IC50 = 300 nM). Has positive chronotropic, ionotropic, and vasodilatory effects on the heart.
A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 300 nM). Has positive chronotropic, inotropic, and vasodilatory effects on the heart.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PDE 3
Product does not compete with ATP.
Reversible: no
Target IC50: 300 nM against PDE III
Warning
Toxicity: Toxic (F)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Other Notes
Bailey, J.M., et al. 1994. Anesthesiology 81, 616.
Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol.20, 705.
Lindgren, S.H., et al. 1990. Acta. Phys. Scand.140, 209.
Harrison, S.A., et al. 1986. Mol. Pharmacol.29, 506.
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Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51111839
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 475840-10MG