MIP-1 alpha/CCL3, also known as LD78 alpha, is an inflammatory chemokine. MIP-1a belongs to the CCL chemokine family, and shares 68% homology with MIP-1ß. The mature form of MIP-1a contains 69 amino acids, exists as dimers in solution, and tends to undergo reversible aggregation. The receptors of MIP-1a in vivo are mainly the G-protein coupled receptors CCR1 and CCR5. Upon stimulation by endogenous and exogenous agents such as Interleukin-1ß, Interferon-?, and lipoteichoic acid from Gram-positive bacteria, monocytes are able to secrete significant amounts of MIP-1a. MIP-1a augments the adhesions of T lymphocytes, monocytes, and neutrophils to vascular cell adhesion molecule 1. In addition, in wounds, MIP-1a chemo-attracts macrophages in order to accelerate the tissue repair process. Recombinant human MIP-1 alpha/CCL3 (rhMIP-1 alpha) produced in E. coli is a single non-glycosylated polypeptide chain containing 70 amino acids. A fully biologically active molecule, rhMIP-1 alpha has a molecular mass of 7.8 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
- UPC:
- 41141965
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- Z03131-10
