Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM) , with an IC 50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammationIn VivoMizacorat (15 mg/kg/day, Oral gavage daily for 8 days) treatment shows excellent in vivo efficacy in a rat model of joint inflammation . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Antigen-induced joint inflammation model in female Lewis rats (175-200 g), sensitized by an intra-articular injection of 5 μg of SCW . Dosage: 15 mg/kg/day. Administration: Oral gavage daily for 8 days. Result: Inhibited ankle swelling in the rat SCW model.Form:SolidIC50& Target:IC50: 3.8 nM (Glucocorticoid receptor). Specification: 0.99 Molecular Formula: C27H28F2N4O3 Molecular Weight: 494.53 PubChem CID: 121248172 Isomeric SMILES: CC(C)[C@@H]([C@@H](C1=CC=CC=C1)OC2=CC3=C(C=C2)N(N=C3)C4=CN(C(=O)C=C4)C)NC(=O)C(C)(F)F
- UPC:
- 12352205
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- M650053-5mg
- CAS:
- 1893415-00-3
- Product Size:
- 5mg
