MK-0159 (C005B-308665)

Catalog No.: C005B-308665
Mfr. No.: SML3630-25MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 1
UOM: EA

Price: $767.15

List Price: $852.39

Biochem/physiol Actions MK-0159 is an orally active, potent and selective CD38 inhibitor (h/m/r CD38 IC50 = 22/3/70 nM) that increases extra- and intracellular NAD+ levels in high CD38-expressing human epithelial A549 cultures, as well as

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Biochem/physiol Actions

MK-0159 is an orally active, potent and selective CD38 inhibitor (h/m/r CD38 IC50 = 22/3/70 nM) that increases extra- and intracellular NAD+ levels in high CD38-expressing human epithelial A549 cultures, as well as intracellular NAD+/NADP+ in HMVECs (0.3-50 µM). MK-0159 (3-30 mg/kg p.o.) increases systemic NAD+ and decreases ADPR levels in mice, providing protection from myocardial damage upon cardiac I/R injury in vivo (30 mg/kg p.o.).

UPC:: 51262006
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML3630-25MG
CAS:: 2641484-61-7

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