ML162 (C005B-310486)

Catalog No.: C005B-310486
Mfr. No.: SML2561-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $234.68

List Price: $260.76

Biochem/physiol Actions ML162 is a small molecule that induces ferroptosis via covalent inhibition of cellular phospholipid glutathione peroxidase (GPX-4: GPX4: GSHPx-4: PHGPx: snGPx: snPHGPx). Synthetic lethality studies in cancer cultures

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Biochem/physiol Actions

ML162 is a small molecule that induces ferroptosis via covalent inhibition of cellular phospholipid glutathione peroxidase (GPX-4; GPX4; GSHPx-4; PHGPx; snGPx; snPHGPx). Synthetic lethality studies in cancer cultures identify contributing factors such as HRas(G12V) expression and fumarate hydratase (FH) deletion to ML162 sensitivity (IC50 = 25 nM & 35 nM, respectively, in BJeLR-HRas(G12V) & UOK262-FH-/- cultures).

UPC:: 51192442
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML2561-5MG
CAS:: 1035072-16-2

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