ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183 ) with an IC 50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC 50 =6.24 nM). ML401 shows good stability and no toxicityIn VitroML401 shows no toxicity (>50 μM) towards immortalized Fa2-N4 human hepatocytes and non-cytotoxic in MTT in both LnCap and IMR-32 cells (>50 μM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoML401 shows very good stability in both human plasma and mouse plasma . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC50: 1.03 nM (EBI2). Specification: 0.99 Molecular Formula: C20H20BrClN2O Molecular Weight: 419.7 PubChem CID: 73169083 Isomeric SMILES: C1CN(CCN1CC2=CC=C(C=C2)Cl)C(=O)/C=C/C3=CC=C(C=C3)Br
- UPC:
- 41115700
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- M648811-1mg
- CAS:
- 1597489-14-9
- Product Size:
- 1mg
