An analog of adenosine 5'-monophosphate that selectively inhibits NAE (IC50 = 4.7 nM) and disrupts CRL-mediated protein turnover leading to apoptosis in cancer cells by deregulating S-phase DNA synthesis.
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An analog of adenosine 5'-monophosphate that selectively inhibits NAE (IC50 = 4.7 nM) and disrupts CRL-mediated protein turnover leading to apoptosis in cancer cells by deregulating S-phase DNA synthesis.
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