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mlt-748 (c09-0967-674)

MLT-748 (C09-0967-674)

Aladdin

Catalog No.
C09-0967-674
Manufacturer No.
M414254-10mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA
Price: $548.28
List Price: $609.20

InformationMLT-748 MLT-748 is a potent, selective and allosteric inhibitor of MALT1 with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive

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InformationMLT-748 MLT-748 is a potent, selective and allosteric inhibitor of MALT1 with IC50 of 5 nM, binding at the interface between the caspase and immunoglobulin (Ig3) domains by displacing Trp580 and locking the catalytic site in an inactive state.TargetsMALT1 (Cell-free assay) 5 nMIn vitroMLT-748 binds MALT1 in the allosteric Trp580 pocket. MLT-748 binds and stabilizes mutant MALT1-W580S. Cleavage of MALT1 substrates is blocked by MLT-748 in B and T cells. MLT-748 rescues MALT1 function in patient MALT1mut/mut lymphocytes.Cell Research(from reference)Cell lines：Immortalized B cells, human PBMCs, primary human CD3+ T cells, primary CD4+ lymphocytes Concentrations：2 μM Incubation Time：24 h. Specification: 0.99 Molecular Formula: C19H19Cl2N9O3 Molecular Weight: 492.32 PubChem CID: 129072285
UPC:
12352208
Condition:
New
Availability:
8-12 weeks
Weight:
1.06 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
M414254-10mg
CAS:
1832578-30-9
Product Size:
10mg


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