MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC 50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC 50 of 12.7 nMIn VitroMM-589 (0.01-10 µM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MV4-11 and MOLM-13 cells Concentration: 0.01, 0.1, 1, 10 μM Incubation Time: 4 days or 7 days Result: Potently inhibited MV4-11 and MOLM-13 cell growth with IC 50 s of 0.25 and 0.21 μM, respectively. Had much weaker activity in the inhibition of cell growth of the HL-60 cell line with an IC 50 of 8.6 μM.Form:SolidIC50& Target:IC50: 0.90 nM (WDR5), 12.7 nM (HMT), Ki: <1 nM (WDR5). Specification: 0.98 Molecular Formula: C30H45F3N8O7 Molecular Weight: 686.72
- UPC:
- 51201900
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- M647424-1mg
- CAS:
- 2253167-09-6
- Product Size:
- 1mg
