General description
A selective, competitive antagonist of leukotriene D4 (LTD4) (Ki = 2.1 nM for inhibition of [3H]LTD4 binding to human lung membranes). Also inhibits multidrug resistance-associated protein 1 (MRP1).
A selective, competitive antagonist of leukotriene D4 (LTD4) receptor (Ki = 2.1 nM for inhibition of [3H]LTD4 binding to human lung membranes). Also reported to inhibit multidrug resistance-associated protein 1 (MRP1).
Biochem/physiol Actions
Primary Target
Antagonist of leukotriene D4 (LTD4)
Target Ki: 2.1 nM for inhibition of [3H]LTD4 binding to human lung membranes
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions in are stable for up to 1 week at -20°C; DMSO stock solutions are stable for up to 6 months at -20°C. Acidic pH and heavy metals will accelerate decomposition.
Other Notes
Olson, D.P., et al. 2001. Cytometry46, 105.
Van der Kolk, D.M., et al. 1998. Clin. Cancer Res.4, 1727.
Jones, T.R., et al. 1989. Can. J. Physiol. Pharmacol.67, 17.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51311607
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 475874-5MG
- Product Size:
- 5MG
- CAS:
- 115104-28-4
