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MNTMPYP 1PC X 25MG (C15-1303-832)

Sigma Aldrich

Catalog No.
C15-1303-832
Manufacturer No.
475872-25MG
Manufacturer Name
Sigma-Aldrich
Quantity
25
Unit of Measure
MG
Price: $267.54
List Price: $297.26

Cell-permeable superoxide dismutase (SOD) mimetic. Catalyzes the dismutation of O 2 – • (rate constant ~4 x 10 7 M -1 s -1 ) even in the presence of excess EDTA.

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General description

Cell-permeable superoxide dismutase (SOD) mimetic. Catalyzes the dismutation of O2– • (rate constant ~4 x 107 M-1 s-1) even in the presence of excess EDTA. Can substitute for SOD in mutants of E. coli lacking this enzyme. MnTMPyP acts in vivo as an NADPH/GSH:O2 oxidoreductase rather than as an SOD mimetic. Also an efficient peroxynitrite reductase when redox-coupled with biological antioxidants.

Biochem/physiol Actions

Cell permeable: yes

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Other Notes

Izbicka, E., et al. 1999. Cancer Res.59, 639.
Lee, J., et al. 1998. J. Am. Chem. Soc. 120, 6053.
Gardner, P.R., et al. 1996. Arch. Biochem. Biophys. 325, 20.
Liochev, S.I., and Fridovich, I. 1995. Arch. Biochem. Biophys. 321, 271.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 1433.53. Empirical Formula: C72H65MnN8O13S4. Quality Level: 100. Assay: ≥. 95% (TLC). form: solid. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze, desiccated, protect from light. color: black. solubility: water: 1 . mg/mL. shipped in: ambient. storage temp.: −. 20°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.
UPC:
41141931
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
475872-25MG

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