Molecular Biology

A cell-permeable triaryl substituted imidazolo compound that acts as a potent, reversible and relatively specific ATP-competitive inhibitor of CK1 (IC 50 = 0.2 &#181M from S.

Amino Acid Sequence Arg-Arg-Lys-Asp-Leu-His-Asp-Asp-Glu-Glu-Asp-Glu-Ala-Met-Ser-Ile-Thr-Ala Specificity V max with casein kinase-1 is 6-fold higher than for casein. Rate of phosphorylation by casein kinase-2 is negligible.

Amino Acid Sequence Arg-Arg-Lys-Asp-Leu-His-Asp-Asp-Glu-Glu-Asp-Glu-Ala-Met-Ser-Ile-Thr-Ala Specificity V max with casein kinase-1 is 6-fold higher than for casein. Rate of phosphorylation by casein kinase-2 is negligible.

A cell-permeable benzotriazolo compound that acts as a highly selective, ATP/GTP-competitive casein kinase II (CKII) inhibitor (IC50 = 900 nM and 1.6 &#181M for rat liver and human recombinant CKII, respectively) and DYRK (IC 50 &lt1 &#181M for

A cell-permeable thiazolamide compound that acts as a potent, reversible, and ATP-competitive inhibitor against casein kinase-2/CK2 (IC 50 = 32 and 46 nM against CK2&#945 and CK2&#945&#8242, respectively), as well as DYRK1B and FLt-3 (82% and

A cell-permeable halogenated benzimidazole compound that acts as a selective and ATP competitive inhibitor of casein kinase II (CK2, K i = 70 nM for the active hetero-tetrameric form). However, its effect on free CK2a and CK2a&#8242 subunits is

Note: 1 KU = 1000 units. Recombinant, human casein kinase II expressed in E.

A set of eight ready to use cell-permeable, irreversible inhibitors of various caspase-family proteases. Contains 25 &#181l (2 mM) each of Caspase-1 Inhibitor VI, Z-YVAD-FMK (Cat.

An irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes.

An irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes.

A highly selective, competitive, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles such as glutathione,

Recombinant, human caspase-1 fused at the N-terminus to a His&#8226Tag sequence and expressed in E. coli .