Molecular Biology

A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (&lt1 min 95% inhibition at 50 &#181M K i = 4.3 &#181M in CFTR-expressing FRT cells for apical

A cell-permeable aminopyrimidine compound that acts as potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC 50 = 10 and 6.7 nM against GSK-3&#945 and GSK-3&#946, respectively).

A potent inhibitor of Janus Protein tyrosine Kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC 50 = 15 nM for murine JAK1), JAK2 IC 50 = 1 nM), JAK3 (K i = 5 nM), and Tyk2 (IC 50 = 1 nM).

A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC 50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP.

A cell-permeable, reversible, and ATP-competitive inhibitor against multiple protein kinases, including, but not limited to, CaM kinase II (K i = 1.8 nM), myosin light chain kinase (K i = 20 nM), protein kinase A (K i = 18 nM), protein kinase C (K

A cell-permeable protein kinase inhibitor that inhibits CaM kinase II (K i = 1.8 nM), myosin light chain kinase (K i = 17 nM), protein kinase A (K i = 18 nM), protein kinase C (K i = 25 nM), and protein kinase G (K i = 20 nM).

A cell-permeable quinazoline compound that acts as a potent inhibitor of NF-&#954B transcriptional activation (IC 50 = 11 nM in Jurkat cells) and LPS-induced TNF-&#945 production (IC 50 = 7 nM in murine splenocytes). Does not exhibit cellular

A cell-permeable, potent, selective, and ATP-competitive inhibitor of p38 MAP kinase (IC 50 = 380 nM for p38&#945). Shown to effectively suppress LPS-induced cytokine release in vitro (IC 50 = 160 nM for TNF-&#945 release and 39 nM for IL-1&#946

A cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC 50 = 4 &#181M and 8 &#181M for PTP1B 403 and PTP1B 298 , respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B

A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK K i = 1.6 nM).

A cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in

A cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of TGF-&#946 type I receptor (ALK5 IC 50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-&#946 cellular assay in HepG2 cells,