Molecular Biology

N-terminal 6His-tagged, recombinant, human Itk, amino acids 352-617. Product Source: Human Itk expressed by baculovirus in Sf21 cells.

Contains iTRAQ &#174 Reagents 113, 114, 115, 116, 117, 118, 119 and 121 and sufficient material for five 8-plex assays. Multiplex Buffer kit ( Cat.

Contains sufficient reaction solutions, test mixture and iTRAQ &#174 Reagents 114, 115, 116 and 117 (for 25 &#956g protein) to label 10 duplex, 6 three-plex or 5 four-plex experiments. Application This iTRAQ application kit for protein provides

Homozygous: Yes Cell Line Description This cell line is an Epstein-Barr Virus (EBV) transformed lymphoblastoid line and is part of the Human Leukocyte Antigen (HLA) Typed Collection maintained by the European Collection of Cell Cultures (ECACC).

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all

A cell-permeable xanthenedione compound that acts as a JAK2-selective inhibitor. It exhibits much less effect on the cellular phosphorylation levels of Jak1 and Src and shows no significant inhibition towards a panel of 49 other protein kinases in

An aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the constitutively active V617F mutant (IC 50 = 78 and 206 nM, respectively) frequently found in patients with clonal polycythemia vera, essential

C-terminal His6-tagged, recombinant, human JAK2, amino acids 808-end, expressed by baculovirus in Sf21 cells Product Source: recombinant, human JAK2, amino acids 808-end Application Research Category Inflammation &amp Immunology Biochem/physiol

A cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3) (IC 50 = 78 &#181M). Has no effect on either JAK1, JAK2, Zap/Syk or Src kinases.

A potent, cell-permeable, reversible, ATP-competitive, and specific inhibitor of JAK3 (IC 50 = 5.6 &#181M).

A cell-permeable 3&#8242-pyridyl oxindole compound that acts as a potent and reversible inhibitor of JAK3 (IC 50 = 27 nM)and displays ~16-fold greater selectivity over JAK2. Binds to the enzyme active site and prevents IL-2-induced cellular