Molecular Biology Reagents

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A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, reversible, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK K i = 1.6 nM).

A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, reversible, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK K i = 1.6 nM).

A cell-permeable indolopyridine compound that acts as a selective, reversible, and ATP-competitive inhibitor of Rho kinase activity with an IC 50 of 25 &#181M. Does not inhibit the activation of Rho kinase nor does it affect the in vitro

A cell-permeable pyridylthiazolyl-urea that acts as a potent, ATP site-targeting, Rho Kinase inhibitor (IC 50 = 14.5 and 6.

A cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of G&#945 12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment

RNA interference experiments using siRNArequire a transfection reagent specificallyoptimized for siRNA delivery. RiboJuice siRNA Transfection Reagent efficiently deliverssiRNA into a wide range of mammaliancell lines for targeted gene suppression.

RNA interference experiments using siRNArequire a transfection reagent specificallyoptimized for siRNA delivery. RiboJuice siRNA Transfection Reagent efficiently deliverssiRNA into a wide range of mammaliancell lines for targeted gene suppression.

A cell-permeable bis -benzylidine piperidone that covalently modifies RPN13/ADRM1 via Michael addition between its electrophilic enone and the nucleophilic RPN13 Cys88, most likely freeing pleckstrin-like receptor for ubiquitin (Pru) domain from

The racemic mixture of a cell-permeable dihydropteridinone that acts as a potent and selective RSK inhibitor (IC 50 &#880431 nM against RSK1, 2, 3, and 4 [ATP] = 100 &#181M) by targeting RSK N-terminal kinase domain in an ATP-competitive manner,

A cell-permeable Kaempferol (Cat. No.

A cell-permeable piperazinyl-pyrimidine compound that acts as an inhibitor against S6K1 (K i = 20 nM IC 50 = 160 nM) and MSK1 (IC 50 = 950 nM) kinase activity, exhibiting little or much reduced potency against 85 other protein and lipid kinases