Molecular Biology Reagents

Application Serine hydrolase inhibitors are small molecule fragments that react in vitro with the serine hydrolase class of proteins. They are amenable to further modification to create novel inhibitors of this class of protein.

A cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC 50 = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency

Reversed-phase silica gels are generally suitable to retain catalysts by hydrophobic interactions. Application Silica gel C 8 -reversed phase was used in the purification of tertiary sulphonamide using FSPE.

Application Silica nanoparticles play a crucial role in biotechnology including bone engineering and drug delivery . The amino functionality present on the surface of these materials provides a synthetic handle for further modification and

Composition of nanoparticles non-crystalline colloidal SiO 2 particles Dispersion loading and medium (27 ± 3) wt.-% in water Particle size d90 (volume distribution DLS) &lt 50 nm pH 2 ± 1 Density (1.

A cell-permeable entiomerically pure compound that is structurally similar to and exhibits similar potency (IC 50 = 63 nM) and selectivity as SIRT1 Inhibitor III (Cat. No.

A cell permeable, benzylsulfonamide that inhibits SIRT2 activity (IC 50 = 12.5 &#181M through enzymatic assay) by targeting the SIRT2 nicotinamide binding site, but may also target SIRT1 and SIRT3 (IC 50 &gt40 &#181M) with much less potency.

A cell-permeable quinoline compound that targets the nicotinamide-binding site and acts as a reversible sirtuin 2- (SIRT2) selective inhibitor (IC 50 = 3.5 &#181M) with little activity against SIRT1/3 (IC 50 &gt50 &#181M).

SM(PEG)n NHS- and maleimide-activated PEG compounds for crosslinking between primary amines (NH2) and sulfhydryl (SH) groups in proteins and other molecules. A complete set of compounds are offered, each having the same heterobifunctional structure

Unit Definition One unit will produce 1.0 &#956mole of choline from L -&#945-glycerophosphorylcholine, G4007, per min at pH 8.

A cell-permeable 1,3-disubstituted urea compound that displays anti-hypertensive and anti-inflammatory properties. Acts as a potent, selective, competitive, and tight-binding transition-state analog inhibitor of soluble epoxide hydrolase (sEH IC

Product Source: E. coli RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover.