Molecular Biology Reagents

A cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of TGF-&#946 type I receptor (ALK5 IC 50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-&#946 cellular assay in HepG2 cells,

A cell-permeable triarylimidazole compound that is shown to effectively inhibit cellular Smad2 phosphorylation (&gt90% inhibition by 10 &#181M inhibitor) upon vector-mediated expression of constitutively active ALK4, ALK5, or ALK7 in NIH 3T3

A cell-permeable cyclohexenecarboxylate that disrupts TLR4 interaction with adaptor molecules TIRAP and TRAM by selectively binding to TLR4, but not TLR1-3 or TLR5-10, via TLR4 intracellular Cys747 residue. Shown to effectively inhibit

Application IRAK-1/4 inhibitor I has been used in various studies to inhibit IRAK1 in hepatoma cell lines and head and neck squamous cell carcinoma (HNSCC) cell lines. Biochem/physiol Actions IRAK-1/4 Inhibitor I is a novel benzimidazole that is a

Application IRAK-1/4 inhibitor I has been used in various studies to inhibit IRAK1 in hepatoma cell lines and head and neck squamous cell carcinoma (HNSCC) cell lines. Biochem/physiol Actions IRAK-1/4 Inhibitor I is a novel benzimidazole that is a

Biochem/physiol Actions Cell permeable: yes Reversible: yes Packaging Packaged under inert gas Warning Toxicity: Standard Handling (A) Legal Information CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

A cell-permeable coumarin o -hydroxyaldehyde compound that inhibits IRE1 RNase activity in a time- and dose-dependent manner (IC 50 = 550, 230, 180, 100, and 45 nM, respectively, with 0, 2, 4, 8, 16, min drug preincubation in FRET-based RNA

Isobutyl chloroformate is used as a peptide reagent. In oligonucleotide synthesis, IBCF blocks the 5&#8242-hydroxyl function of deoxyribosides.

Isobutyl chloroformate is used as a peptide reagent. In oligonucleotide synthesis, IBCF blocks the 5&#8242-hydroxyl function of deoxyribosides.

Isopropyl 3-Amino-4-Chlorobenzoate.

Isopropyl 3-Amino-4-Chlorobenzoate.

A cell-permeable xanthenedione compound that acts as a JAK2-selective inhibitor. It exhibits much less effect on the cellular phosphorylation levels of Jak1 and Src and shows no significant inhibition towards a panel of 49 other protein kinases in