Molecular Biology Reagents

A cell-permeable methylsulfanylimidazole compound that acts as a potent, selective, reversible, and ATP-competitive p38 MAP kinase inhibitor (IC 50 = 0.38 &#181M for p38&#945).

A cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38&#945/&#946 MAPK (IC 50 = 130 and 550 nM, respectively), while exihibiting much reduced activity (&#880423% inhibition at 1 &#181M) against

A cell-permeable indole compound that acts as a potent, ATP-competitive, and isozyme-selective p38&#945 MAP kinase inhibitor (IC 50 = 3.2 nM).

A cell-permeable pyrazolo-napthalenyl urea compound that acts as a highly potent, slowly binding (IC 50 = 8 and 97 nM, respectively, against human p38&#945, respectively, with or without 2 h preincubation), but high affinity (t 1/2 of dissociation

A cell-permeable, water soluble and specific p53-Snail binding inhibitor that activates p53 in a K-Ras-dependent manner and displays anti-proliferating effect toward K-Ras-MEF (K-Ras-transformed mouse embryonic fibroblast) cells with 20% viability

The p75 NTR inhibitor Pep5 (Cat. No.

BD supplies more than 400 different BD Difco™ and BD BBL™ brand media formulations and ingredients in dehydrated form for the convenience of the laboratorian and bioprocessing specialist.

A cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC 50 &lt33 nM). Shown to act as an ATP-competitive and reversible inhibitor of PDGFR (IC 50 = 4.

A cell-permeable quinolinyl-thiourea compound that acts a potent, ATP-competitive, and reversible inhibitor of PDGFR (IC 50 = 4 and 7.6 nM in ligand-induced cellular PDGFR phosphorylation and in in vitro kinase activity, respectively).

A cell-permeable pyrrolopyrimidinamine compound that acts as a potent, ATP-competitive EIF2AK3/PERK inhibitor (IC 50 = 0.9 nM [ATP] = 10 &#181M), displaying &#8805511-fold selectivity over HRI/EIF2AK1, BRK, PKR/EIF2AK2, and MEKK2 (IC 50 = 460,

A cell-permeable isoflavone compound that acts as a potent and competitive inhibitor of fructose-2,6-bisphosphatase 3 (PFKFB3 IC 50 = 670 nM K i = 240 nM). Directly docks into the Fru-6-P binding pocket of PFKFB3 and down-regulates Fru-2,6-BP

Phenol, also known as hydroxybenzene, is a significant benzene derivative in commercial applications. It serves as a fundamental feedstock to produce polycarbonates, epoxy resins, molding compounds, and phenolic resins.