Molecular Biology Reagents

A cell-permeable and specific activator of phospholipase C (PLC). Reported to stimulate PLC-mediated intracellular Ca 2+ release, inositol phosphate production, and superoxide generation in various cell types.

N-terminal 6His-tagged, recombinant, human Pim-3 Biochem/physiol Actions Protein Target: Pim-3 Quality routinely evaluated by phosphorylation of 250&#956M GGMEDIYFEFMGGKKK Other Notes For Specific Activity data, refer to the Certificate of

An orally bioavailable oxindolo-furanyl compound that acts as a potent, reversible and ATP-competitive inhibitor of pan PIM-kinases (IC 50 = 5, 25 and 16 nM for PIM-1, PIM-2 and PIM-3, respectively K i = 5 nM for PIM-1) with excellent selectivity

N-terminal GST-tagged recombinant human full length Pim-1 Product Source: expressed in E. coli cells Application Research Category Inflammation &amp Immunology Biochem/physiol Actions Protein Target: Pim-1 Target Sub-Family: CAMK Packaging Also

A cell-permeable thiazolidinedione compound that acts as a potent, ATP-competitive inhibitor against Pim-1/2 kinases (IC 50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1&#945 (68% inhibition of DYRK1&#945 and Pim-2 at

Product Source: N-terminal GST-tagged recombinant full-length human PIM2 human PIM2 expressed in E. coli, purified using GSH agarose Quality routinely evaluated by phosphorylation of PIM2tide Physical form GSH agarose Other Notes For Specific

A cell-permeable hydroxyphenyl-propylidene-benzohydrazide compound that acts as a potent, ATP-competitive (K i = 0.3 &#181M), and highly isoform-selective PIM inhibitor (IC 50 = 2.

Application PK 11195 has been used as an inhibitor of peripheral benzodiazepine receptor (PBR) homologs in primitive erythrocytes of embryos and in osteosarcoma cytoplasmic hydrids. It has also been used as an unlabelled competitive binder in in

Application PK 11195 has been used as an inhibitor of peripheral benzodiazepine receptor (PBR) homologs in primitive erythrocytes of embryos and in osteosarcoma cytoplasmic hydrids. It has also been used as an unlabelled competitive binder in in

Contains 250 &#181g of Bisindolylmaleimide I (Cat. No.

Epidermal growth-factor receptor (EGF-R) conserved sequence which is identical to v- erb B (95-102). An N-terminal myristoylated membrane-permeable, reversible, and substrate competitive inhibitor that inhibits protein kinase C (IC 50 = 5 &#181M)

A cell-permeable symmetrical phthalimide compound that acts as a potent, reversible, and ATP-competitive inhibitor of EGFR and PKC isozymes &#945, &#946I, and &#946II (IC 50 = 0.7 &#181M, 1.