Lipoxygenase Inhibitors

A cell-permeable, non-toxic naphthyl-oxazole compound that acts as a highly potent, selective, active site directed, mixed type inhibitor of lipoxygenase-12/15 (IC 50 = 200 nM for human). The inhibition appears to be non-reductive and reversible in

A cell-permeable benzylidine-thioxothiazolidinone compound that blocks the steroidogenesis of testosterone by directly inhibiting 17&#946-HSD3- (17&#946-hydroxysteroid dehydrogenase type 3) catalyzed, NADPH-dependent, reduction of &#916 4 -dione

Anti-CYP2A6 cytochrome P450, family 2, subfamily A, polypept

Application Developed by Albrecht Berkessel&#8242s lab, this is the first catalyst that allows catalytic enantioselective epoxidation of non-conjugated terminal double bonds with hydrogen peroxide as the oxidant. Eradicating multiple steps and

A cell-permeable and orally available sulfonanilide that acts as a COX-2-selective non-steroidal anti-inflammatory drug (NSAID). Shown to exhibit 500-fold greater potency in inhibiting the LPS-induced (IC 50 = 316 nM in human mononuclear cells)

A cell-permeable 2-OG (2-oxoglutarate) analog that is expected to act as a competitive inhibitor against all 2-OG-dependent dioxygenases. Effectively upregulates normoxia HIF-&#945 transcription activity (effective conc.

A cell-permeable, non-toxic, indolinyl-thiazole based compound that acts as a highly potent, reversible inhibitor of lipid uptake via scavenger receptor class B type I (SR-BI IC 50 = 6 nM). Shown to block the uptake of [ 3 H] labeled cholesteryl

A benzoic acid hydrazide analog that acts as a potent, irreversible, and specific inhibitor of the peroxidation activity of myeloperoxidase (MPO IC 50 = 300 nM). Does not inhibit catalase or glutathione peroxidase activities.

A cell-permeable, stabilized hydrocarbon-stapled &#945-helical peptide that targets a critical protein-protein interface and prevents assembly in the NOTCH1 trans-activation complex. Soluble FITC-SAHM1 was found to bind the pre-formed RAMANK-CSL

PrEST Antigen ADI1 acireductone dioxygenase 1, 100ul UN 1687

PrEST Antigen ALOX12B arachidonate 12-lipoxygenase, 12R type

A cell-permeable 1,3-disubstituted urea compound that displays anti-hypertensive and anti-inflammatory properties. Acts as a potent, selective, competitive, and tight-binding transition-state analog inhibitor of soluble epoxide hydrolase (sEH IC