Phosphodiesterase Inhibitors

The identification of protein phosphorylation as a regulatory mechanism originated from studies by Fischer and Krebs in the mid 1950s that later earned them the 1992 Nobel prize. It is the major mechanism for the regulation of diverse cellular

Histone H1 and the N-terminal tail of histone-3 (H3) have key roles in the folding and inter-association of the chromatin fibers. Two currently known phosphorylation sites are present in the N-terminus of H3 serine-10 and serine-28.

Histone H1 and the N-terminal tail of histone-3 (H3) have key roles in the folding and inter-association of the chromatin fibers. Two currently known phosphorylation sites are present in the N-terminus of H3 serine-10 and serine-28.

Mouse monoclonal antibody purified by thiophilic adsorption and size exclusion chromatography. Recognizes the ~46 kDa GSK-3&#946 phosphorylated at Ser 9 .

PrEST Antigen PIAS3 protein inhibitor of activated STAT, 3,

PrEST Antigen PIAS3 protein inhibitor of activated STAT, 3,

PrEST Antigen PIAS4 protein inhibitor of activated STAT 4, 1

A cell-permeable dithiazolylmethylglycinate that acts as a PTP1B-selective tyrosine phosphatase inhibitor (K i = 220 nM/PTP1B, 9.3 &#181M/TCPTP, &gt30 &#181M/CD45, &gt30 &#181M/LAR Substrate = pNPP, Cat.

Unit Definition One unit will produce 1.0 &#956mole of choline from L -&#945-glycerophosphorylcholine, G4007, per min at pH 8.