Protease Inhibitors

E3 ubiquitin-protein ligase RNF213 (UniProt: Q63HN8 also known as ALK lymphoma oligomerization partner on chromosome 17, Mysterin, RING finger protein 213, RING-type E3 ubiquitin transferase RNF21) is encoded by the RNF213 (also known as ALO17,

A cell-permeable benzothiazolyltetrahydrothienopyridine compound that acts as a potent, competitive, and active site targeting inhibitor of APE1 (IC 50 = 2.0 &#181M in a fluorescence based HTS assay and 12 .

A cell permeable acetylpiperazine derivative compound that acts as a selective and reversible inhibitor of lysophospholipase 1 (LYPLA1 IC 50 = 840 nM, K i = 300 nM) without affecting the activity of LYPLA2 and 25 other serine hydrolases in mouse

Cysteine protease inhibitor. Selectively inhibits cathepsin B (k 2 /K i = 1 x 10 4 M -1 sec -1 ), cathepsin L (k 2 /K i = 1.

A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (K i,app = 6 nM). Shown to completely block cathepsin K activity in primary human synovial fibroblast cultures at 1

A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (K i,app = 9.7 nM).

A cell-permeable, allosteric, trisubstituted dihydropyrazolyl compound that acts as a potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPases (IC 50 = 0.2, 2.

Application Collagenase with protease inhibitor has been used in a study to assess the association of immune system gene polymorphisms with quantitative features. It has also been used in a study to investigate the quantitative structure-activity

A dipeptidylpeptidase IV (DPP IV) inhibitor that inhibits both endo- and exopeptidase activities of DPPIV. A dipeptidylpeptidase IV (DPP IV) inhibitor.

A cyanopyrrolidine compound that acts as a potent DPP IV inhibitor (IC 50 = 3, 5, 8, and 8 nM in inhibiting rat, human, monkey, and canine DDP IV, respectively). Oral administration of K579 in rats in vivo has been shown to reduce blood DPP IV

A cell-permeable dipeptide that inhibits &#947-secretase activity and suppresses A&#946 production (A&#946 total IC 50 = 115 nM A&#946 42 IC 50 = 200 nM). Reported to be functionally active in both HEK293 cells overexpressing human APP751 and

A cell-permeable dipeptide that inhibits &#947-secretase activity and suppresses A&#946 production (A&#946 total IC 50 = 115 nM A&#946 42 IC 50 = 200 nM). Reported to be functionally active in both HEK293 cells overexpressing human APP751 and