Protease Inhibitors

A cell-permeable dibenzazepine (dbz) compound that acts as a potent &#947-secretase inhibitor and significantly lowers both brain and plasma A&#946 40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 &#181mol/kg, b.i.

A cell-permeable dibenzazepine (dbz) compound that acts as a potent &#947-secretase inhibitor and significantly lowers both brain and plasma A&#946 40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 &#181mol/kg, b.i.

A cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of &#947-secretase and Notch processing (IC 50 = 300 pM for A&#946 40 in CHO cells overexpressing wild type &#946APP 240 pM for A&#946 40 , 370 pM for

A cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of &#947-secretase and Notch processing (IC 50 = 300 pM for A&#946 40 in CHO cells overexpressing wild type &#946APP 240 pM for A&#946 40 , 370 pM for

A benzylidene lactam compound that blocks the induction of heat shock proteins HSP70, HSP72, and HSP105. Blocks the development of thermotolerance in a dose-dependent manner.

A cell-permeable oxothiazolo-imidazo-pyridinylidene-benzoate that competitively blocks the activity of hematopoietic protein tyrosine phosphatase (HePTP) (IC 50 = 210 nM K i = 211 nM) and thereby induces sustained hyperactivation of ERK1/2 and p38

A cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC 50 = 2 &#181M in a cell-based assay using a reporter produced by fusing HIF-1&#945 oxygen degradable domain (ODD) to luciferase. This compound (5

A cell-permeable pyrazoloresorcinol compound that inhibits HSP90 ATPase activity (IC 50 = 3.2 &#181M and 6.

A cell-permeable phenylquinolinyl-urea compound that inhibits IGF-1R autophosphorylation (IC 50 = 12 &#181M in inhibiting ligand-induced autophosphorylation in MCF-7 cells and &lt1 &#181M in a cell-free kinase assay). Reduces IGF-1R-dependent

A cell-permeable cis-cyclolignan compound that acts as a substrate competitive, reversible, potent, and specific inhibitor of IGF-1R both in vitro (IC 50 = 1 nM in cell-free kinase assay &#8804 60 nM for cell viability and receptor

Anabaenopeptins are cyclopentapeptides found in cyanobacteria such as Microcystis aeruginosa and Oscillatoria agardhii. Anabaenopeptins and other cyanotoxins are typically inhibitors of serine proteases and protein phosphatases (PPs).

Anabaenopeptins are cyclopentapeptides found in cyanobacteria such as Microcystis aeruginosa and Oscillatoria agardhii. Anabaenopeptins and other cyanotoxins are typically inhibitors of serine proteases and protein phosphatases (PPs).