Protease Inhibitors

Anabaenopeptins are cyclopentapeptides found in cyanobacteria such as Microcystis aeruginosa and Oscillatoria agardhii. Anabaenopeptins and other cyanotoxins are typically inhibitors of serine proteases and protein phosphatases (PPs).

Anabaenopeptins are cyclopentapeptides found in cyanobacteria such as Microcystis aeruginosa and Oscillatoria agardhii. Anabaenopeptins and other cyanotoxins are typically inhibitors of serine proteases and protein phosphatases (PPs).

A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC 50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP.

A cell-permeable quinazoline compound that acts as a potent inhibitor of NF-&#954B transcriptional activation (IC 50 = 11 nM in Jurkat cells) and LPS-induced TNF-&#945 production (IC 50 = 7 nM in murine splenocytes). Does not exhibit cellular

A cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in

Biochem/physiol Actions Cell permeable: yes Reversible: yes Packaging Packaged under inert gas Warning Toxicity: Standard Handling (A) Legal Information CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

A cell-permeable coumarin o -hydroxyaldehyde compound that inhibits IRE1 RNase activity in a time- and dose-dependent manner (IC 50 = 550, 230, 180, 100, and 45 nM, respectively, with 0, 2, 4, 8, 16, min drug preincubation in FRET-based RNA

A cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC 50 = 7 nM), inhibiting JNK1 only at much higher concentrations (IC 50 = 170 nM) and exhibiting little activity against p38

A cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC 50 = 1.6 &#181M in DLD-1 cells).

Cell Line Origin Mouse Sp2/0 x Mouse BALB/c spleen Cell Line Description Antibodies secreted by the hybridoma line MCP21 react with subunit C3 in human and rabbit proteasomes, both with intact proteasomes and on blots. The hybridoma has been

A cell-permeable acrylonitrile compound that inhibits the kinesin-6 family member MKLP-2 (Mitotic kinesin-like protein 2 IC 50 against basal and microtubule-/MT-stimulated ATPase activity = 1.35 and 0.

A cell-permeable pyrazolopyrimidine that selectively inhibits MRP1. It is shown to increase the efficacy of vincristine and etopiside by 10- to 15-fold and 7- to 10-fold, respectively, over either of these two MRP1 substrate drugs alone in murine