Monoclonal Anti-C-Reactive Protein antibody produced in mouse (C15-1346-388)

General description

C-reactive protein (CRP) is a member of the pentraxin family of proteins and synthesized by the liver. It is also known as PTX1. The CRP gene is mapped to human chromosome 1q23.2.

Specificity

The antibody recognizes an epitope located on the 24 kDa subunit of denatured and reduced CRP. It does not cross-react with human serum amyloid P component (SAP), human haptoglobin, human α₁-acid glycoprotein, human IgG, and CRP from Limulus.

Immunogen

human C-reactive protein.

Application

• It has been used in immunoblotting assay, to identify monomeric CRP.
• In time-resolved fluorometric assay.

Monoclonal Anti-C-Reactive Protein antibody produced in mouse is suitable for the following:

• dot blot analysis
• indirect ELISA at a working dilution of 1:40,000
• western blotting at a working dilution of 1:200

Biochem/physiol Actions

C-reactive protein (CRP) shows essential scavenging and metabolic activity and is also associated with defence mechanism. It activates the complement pathway by binding to calcium-dependent exogenous and autologous molecules containing phosphocholine (PC). It may have pathogenic effects and is a practical prognostic marker in patients with hepatocellular carcinoma (HCC). The CRP diagnostic value is higher for acute pyelonephritis than lower urinary tract infection. Thus, it helps in differentiating between upper and lower urinary tract infection. It is considered best for predicting the risk of cardiovascular disease..

Disclaimer

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