MONOCLONAL ANTI-CACNA1D ANTIBODY PRODUCED IN MOUSE

General description

Calcium channel, L type α-1 polypeptide isoform 2 (CACNA1D) is expressed in many tissues and possesses six transmembrane segments, along with a loop lining the pore of the channel. The gene encoding CACNA1D is localized on human chromosome 3p14.3.

Specificity

Detects ~250 kDa. No cross-reactivity against Cav1.2

Immunogen

Fusion protein amino acids 859-875 of rat Cav1.3, Accession Number P27732

Application

Monoclonal Anti-CACNA1D antibody produced in mouse has been used in immunocytochemistry.

Biochem/physiol Actions

Calcium channel, L type α-1 polypeptide isoform 2 (CACNA1D) is crucial for the functioning of the brain and in hearing. It gets activated at a fast rate and withstands high inward Ca²⁺ currents even at threshold voltages. CACNA1D aids in dendritic signals linked to mitochondrial stress in the brain and is important for estrogen-stimulated Ca²⁺ influx. Studies have shown that in atrial myocytes, the C terminus of the channel translocates to the nucleus and regulates Ca²⁺-activated K⁺ channels. CACNA1D was shown to be upregulated in endometrial cancer and its knockdown showed a reduction in cell proliferation in vitro. Mutations in the gene encoding it has been associated with aldosterone-producing adenomas (APAs), where it leads to the formation of small adenomas.

Features and Benefits

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Physical form

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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