General description
CD63 belongs to the transmembrane 4 superfamily (TM4SF). CD63 is an integral membrane glycoprotein expressed in late endosomes and lysosomes, and is also present in the platelet dense granule membrane.
Immunogen
HPB-ALL T cell line
Application
The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.
Biochem/physiol Actions
CD63 is one of the platelet activation marker, which plays a vital role in platelet aggregation, adhesion to collagen, uptake of oxidized low-density lipoprotein (LDL) in vitro and regulation of angiogenesis. Improved metabolic control deduce platelet activation marker in the type-2 diabetes patients and helps in reducing development of diabetic late complications. Inadequate expression of CD63 results in the autosomal recessive inherited disorder, Hermansky-Pudlak syndrome. CD63 is associated with various cellular functions such as cellular adhesion, cell differentiation, migration, carcinogenesis, and tumor progression. CD63 is highly expressed in initial stage of Merkel cell carcinoma and decreased in later stages; therefore, CD63 is considered to be a potential prognostic factor for this malignancy.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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- UPC:
- 51183600
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- SAB4700217-100TST
- Temperature Control Device:
- Yes
