General description
The gene IFI-16 (interferon, γ-inducible protein 16) encodes a member of the interferon-inducible nuclear proteins family containing one or two copies of a conserved 200 amino acid repeat domain called HIN-200 domain. It has three different isoforms, IFI-16A, -16B, -16C. The IFI-16A isoform is the longest with 785 amino acids. IFI-16B is the most broadly expressed isoform with 729 amino acids and IFI-16C has 56 amino acids lesser. The three isoforms have serine and threonine residues which can be phosphorylated. The N-terminus contains an imperfect leucine zipper domain, where the isoforms homo- and heterodimerize. IFI-16 contains an N-terminal domain called DAPIN/PYRIN/CARD that may be involved in protein–protein interactions. IFI-16 is expressed in some haemopoietic lineages , such as CD34+ progenitor cells, mature lymphocytes and monocytes. The gene is mapped to human chromosome 1q22.
Immunogen
synthetic peptide corresponding to amino acids 768-783 at the C-terminus of human IFI-16.
Biochem/physiol Actions
The gene IFI-16 (interferon, γ-inducible protein 16) encodes an interferon-inducible transcriptional modulator from the p200-protein family. It may play a role in negative regulation of transcription. Overexpression of this gene in older populations of human fibroblasts leads to cellular senescence. It is also associated with senescence-associated irreversible cell growth arrest in normal human prostate epithelial cells.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
Disclaimer
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- UPC:
- 12352203
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- I1659-200UL