General description
The gene ICAM3 (intercellular adhesion molecule 3) encodes type I membrane glycoprotein that belongs to the immunoglobulin (ig) superfamily. The encoded protein is extensively glycosylated and contains five Ig-like domains that share high homology with corresponding domains in ICAM-1 and ICAM-2. ICAM3 is found to be expressed on all leukocytes, including the resting leukocytes. The gene is mapped to human chromosome 19p13.2.
Immunogen
stimulated human leukocytes.
Biochem/physiol Actions
The protein intercellular adhesion molecule 3 (ICAM-3) functions as a receptor for LFA-1 (leukocyte function-associated antigen-1) and mediates adhesive interactions of leukocyte cell surface adhesion molecules in inflammatory and immune response. LFA-1 participates in several processes, such as T cell-mediated killing, T helper and B lymphocyte responses, natural killing, Ab-dependent cellular cytotoxicity by monocytes and granulocytes, and adherence of leukocytes to endothelial cells, fibroblasts, and epithelial cells. ICAM-3 mediates the adhesion of resting T lymphocytes to LFA-1 and participates in the initiation of immune responses. It may also function in lymphocyte activation, as well as in adhesion.
Physical form
Solution in phosphate buffered saline pH 7.4, containing 0.08% sodium azide.
- UPC:
- 12352203
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- I9031-100UG
