General description
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases. (provided by RefSeq)
Immunogen
NCOA6 (NP_054790, 1954 a.a. ~ 2063 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
VGSHPELLPSIAPSQNLVSKETSTTALQASVARPELEVNAAIVSGQSSEPKEIVEKSKIPGRRNSRTEEPTVASESVENGHRKRSSRPASASSSTKDITSAVQSKRRKSK
Biochem/physiol Actions
NCOA6 (Nuclear receptor coactivator 6) interacts with nuclear receptors in ligand-dependent or ligand-enhanced dependent manner to regulate nuclear receptor-mediated mammalian gene expression. The activation domain helps to increase the transcriptional activity of several nuclear receptors. It forms a dimer by binding to the liganded receptors, which lead to a structural change in NRC activation. It has also been reported that NCOA6 highly influences the binding of CREB-binding protein (CBP) during transcriptional activity of nuclear hormone receptors.
Physical form
Solution in phosphate buffered saline, pH 7.4
Legal Information
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Disclaimer
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- UPC:
- 12142207
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- WH0023054M1-100UG
- Product Size:
- 100/µG