Monoclonal Anti-NUP153 antibody produced in rat

General description

Nucleoporin 153kDa (NUP153) has a NE (nuclear envelope)-and NPC (nuclear pore complex)-targeting site, four zinc-fingers and a phenylalanine-glycine-repeat. It is part of the FG repeat class of proteins. The gene encoding it is localized to human chromosome 6p22.3.

Immunogen

recombinant protein corresponding to amino acids 610-1191 of rat Nup15.

Application

Monoclonal Anti-NUP153 antibody produced in rat has been used to study binding protein partners for thyroid hormone receptor-β2.

Biochem/physiol Actions

Nucleoporin 153kDa (NUP153) is a nuclear pore protein crucial for nuclear import. It is involved in importin α/β-mediated import and mRNA export from the nucleus. NUP153 is involved in HIV (human immunodeficiency virus)-1 nuclear import and integration. Poliovirus and rhinovirus infection results in the cleavage of this protein, thereby disrupting nucleo-cytoplasmic trafficking. Similarly, cardiovirus infection results in NUP153 phosphorylation, thereby modulating nuclear pore complex. NUP153 also has a role in cell cycle modulation and apoptosis. It associates with lamin B and might have a role in the anchoring of nuclear pore complexes to the nuclear lamina.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.