General description
Transcription factor 4 (TCF4), also known as E2-2, is a helix-loop-helix transcription factor. It is part of the E protein family and is expressed in the cornea during development. The gene encoding TCF4 is localized on human chromosome 18q21.
Immunogen
TCF4 (AAH31056.1, 1 a.a. ~ 365 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHTTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRN
Biochem/physiol Actions
Transcription factor 4 (TCF4) acts a regulator of cellular growth and differentiation. It has a role in the development of central nervous system. Defects in TCF4 gene are associated with Pitt-Hopkins syndrome. The protein has also been linked to susceptibility to schizophrenia.
Physical form
Solution in phosphate buffered saline, pH 7.4
Legal Information
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Disclaimer
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- UPC:
- 12352200
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- WH0006925M2-100UG
- Temperature Control Device:
- Yes
