Mre11 Mouse mAb (C09-0741-949)

Mouse anti Human Mre11 Antibody, Monoclonal antibody, could be used for ELISA, WB, Flow, IHC and so on.Application:WB: 1/500 - 1/2000. Predicted molecular weight: 80.6 kDa. IHC: 1/200 - 1/1000Flow: 1/200 - 1/400ELISA: 1/10000Protein FunctionComponent of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.Post-translationalPhosphorylated upon DNA damage, probably by ATM or ATR. Specifications and Purity: mAb(7C8A9); Mouse anti Human Mre11 Antibody; ELISA, WB, Flow, IHC; Unconjugated.