InformationMRT67307 is a potent and dualIKKϵandTBK1inhibitor with IC50 of 160 and 19 nM, respectively. MRT67307 potently inhibitsULK1andULK2and blocksautophagy.TargetsIKKϵ (Cell-free assay); TBK1 (Cell-free assay) 160 nM; 190 nMIn vitroIn macrophages, MRT67307 prevents the phosphorylation of IRF3 and the production of IFNβ. In wild-type MEFs, MRT67307 enhances the IL-1-stimulated phosphorylation of p105 at Ser933 and RelA at both Ser468 and Ser536, and also enhances IL-1-stimulated activation of NF-κB-dependent gene transcription. MRT67307 increases IL-10 production and suppresses proinflammatory cytokine production via a cAMP response element-Binding protein (CREB)-regulated transcriptional coactivator (CRTC) 3 Dependent Mechanism. In addition, MRT67307 inhibit ULK and block autophagy in MEF cells.Cell Research(from reference)Cell lines：MEFs and 293T cells Concentrations：10 μM Incubation Time：1 h. Specification: 0.98 Molecular Weight: 464.6 (free-base)
- UPC:
- 12352107
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- M413883-25mg
- CAS:
- 1781882-89-0
- Product Size:
- 25mg
