MRTX9768 hydrochloride is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor.Appearance:SolidIC50& Target:PRMT5•MTAIn Vitro:MRTX9768 inhibits SDMA and cell proliferation in HCT116 MTAP-del cells (SDMA IC 50 3 nM; prolif. IC 50 11 nM) with marked selectivity over HCT116 MTAP-WT cells (SDMA IC 50 544 nM; prolif. IC 50 861 nM). MRTX9768 (0-250 nM) results in LU99 SDMA inhibiIn Vivo:In xenograft studies, oral administration of MRTX9768 demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors, with less SDMA modulation observed in bone marrow. MRTX9768 selectively targets MTAP/CDKN2A-deleted tumors (such as glioblastoma)Biological Activity:MRTX9768 hydrochloride is a potent, selective, orally active, first-in-class PRMT5-MTA complex inhibitor. Specifications and Purity: 99%. Molecular Formula: C24H18ClFN6O. Molecular Weight: 460.89.
- UPC:
- 12352107
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.09 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- M659405-5mg
- Product Size:
- 5mg
