InformationMS049 MS049 is a potent and selective inhibitor of PRMT4 and PRMT6 with IC50s of 34 nM and 43 nM, respectively.TargetsPRMT4 (Cell-free assay); PRMT6 (Cell-free assay) 34 nM; 43 nMIn vitroMS049 does not inhibit any of the methyltransferases at 50 μM or demethylases at 10 μM and does not display appreciable binding to any of the methyllysine/methylarginine reader proteins using the DSF assay at 200 μM. MS049 demonstrated excellent selectivity over a broad range of epigenetic and nonepigenetic targets. In cellular assays, MS049 potently inhibits the methyltransferase activity of PRMT4 and PRMT6 and reduces levels of Med12me2a and H3R2me2a in HEK293 cells.Cell Research(from reference)Cell lines：HEK293 cells Concentrations：0, 1, 10, and 50 μM Incubation Time：96 h. Specification: 0.99 Molecular Formula: C15H26Cl2N2O Molecular Weight: 321.29 PubChem CID: 124203907 Isomeric SMILES: CNCCN1CCC(CC1)OCC2=CC=CC=C2.Cl Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/M413920-SCI_76e5dcdf100da49239944c826221e343.pdf
- UPC:
- 41142024
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- M413920-10mg
- CAS:
- 2095432-59-8
- Product Size:
- 10mg
- Hazard Statement Codes:
- H302:H315:H319:H335
- Precautionary Statement Codes:
- P261:P305+P351+P338
