MS140 (C09-0968-069)

Aladdin

Catalog No.: C09-0968-069
Manufacturer No.: M422678-1ml
Manufacturer Name: Aladdin Scientific
Quantity: 1
Unit of Measure: EA

Price: $311.01

List Price: $345.57

InformationMS140 MS140 is a specific and highly potent CDK4/6 kinase inhibitor and also a CDK4/6 degrader (PROTAC).TargetsCDK4 : CDK6In vitroMS140 potently and selectively both inhibits and degrades CDK4/6 kinases in CDK4/6i-S tumor cells by

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Description
Specifications

InformationMS140 MS140 is a specific and highly potent CDK4/6 kinase inhibitor and also a CDK4/6 degrader (PROTAC).TargetsCDK4 ; CDK6In vitroMS140 potently and selectively both inhibits and degrades CDK4/6 kinases in CDK4/6i-S tumor cells by targeting them to the CRL4–CRBN–E3 ubiquitin complex.In vivoTreatment of mice with MS140 promoted degradation of CDK4/6 kinases and suppression of RB–E2F output in JeKo-1 (MCL) and Colo25 (colorectal carcinoma) xenografts in vivo.Cell Research(from reference)Cell lines：Colo205 cells Concentrations：0.3/u2009μM Incubation Time：5/u2009h. Specification: 10mM in DMSO Molecular Formula: C39H40N10O7 Molecular Weight: 760.8 PubChem CID: 134605838

UPC:: 12352208
Condition:: New
Availability:: 8-12 weeks
Weight:: 0.85 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: M422678-1ml
CAS:: 2229974-83-6
Product Size:: 1ml

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