InformationMS4078 is an inhibitor and PROTAC (degrader) of ALK . MS4078 reduces the NPM-ALK protein levels in SU-DHL-1 cells and the EML4-ALK protein levels in NCI-H2228 cells with DC50 of 11 nM and 59 nM, respectively. MS4078 induces ALK protein degradation via cereblon and proteasome dependent mechanism and potently inhibits proliferation of SU-DHL-1 cells with IC50 of 33 nM.TargetsEML4-ALK (Cell-free assay); NPM-ALK (Cell-free assay) ; 11 nM(DC50). Specification: 0.98 Molecular Formula: C45H52ClN9O8S Molecular Weight: 914.47 PubChem CID: 137628668 Isomeric SMILES: CC1=CC(=C(C=C1C2CCN(CC2)CC(=O)NCCNC3=CC=CC4=C3C(=O)N(C4=O)C5CCC(=O)NC5=O)OC(C)C)NC6=NC=C(C(=N6)NC7=CC=CC=C7S(=O)(=O)C(C)C)Cl Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/M412162-SCI_a764b83e2bf4f26a4650947293df4397.pdf
- UPC:
- 51172807
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- M412162-5mg
- CAS:
- 2229036-62-6
- Product Size:
- 5mg
- Hazard Statement Codes:
- H302:H315:H319:H335
- Precautionary Statement Codes:
- P261:P305+P351+P338
