MS645 is a bivalent BET bromodomains (BrD) inhibitor with a K i of 18.4 nM for BRD4-BD1/BD2. MS645 spatially constrains bivalent inhibition of BRD4 BrDs resulting in a sustained repression of BRD4 transcriptional activity in solid-tumor cellsIn VitroMS645 has cell growth inhibitory effects on noncancer cell lines of mouse macrophage RAW cells and nontumorigenic breast epithelial MCF10A with IC 50 s of 4.1 nM, 6.8 nM, 7.9 nM for triple-negative breast cancer (TNBC) cell lines HS5878T, BT549, and MCF 10A. ?/nMS645 (15, 30, 60 nM) results in a dramatic reduction of c-Myc expression and an increase of p21, a tumor suppressor and cell-cycle inhibitor in HCC1806 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:BRD4(BD1BD2) 18.4 nM (Ki). Specification: 10mM in DMSO Molecular Formula: C48H54Cl2N10O2S2 Molecular Weight: 938.04
- UPC:
- 51183104
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- M656887-1ml
- CAS:
- 2250091-96-2
- Product Size:
- 1ml
